Supplementary MaterialsAdditional document 1 – CSF1R inhibitors afford the most extensive versatility in manipulating microglia

Supplementary MaterialsAdditional document 1. CD8 expression. 12967_2019_2194_MOESM1_ESM.tif (50M) GUID:?3CEFDFBA-4BA5-4F13-AA74-8C0244DD7CE4 Additional file 2. Frequency of Treg cells in patients with CML receiving imatinib or 2nd generation TKIs. Panels (A) and (B) summarize the frequency of CD4+ Treg cells in patients with CML receiving imatinib (n?=?26) or 2nd generation TKIs (n?=?1 nilotinib, n?=?2 dasatinib, n?=?3 bosutinib and n?=?1 ponatinib). Panels (C) and (D) depict the frequency of CD8+ Treg cells in the same treatment categories. In the combination treatment group, 6 CML patients were treated with imatinib and 2 CML patients received nilotinib. 12967_2019_2194_MOESM2_ESM.tif Istradefylline (KW-6002) (32M) GUID:?4618E2D9-0372-43B6-BE73-90632B96D146 Additional file 3. Programmed death receptor 1 (PD-1) expression in patients with CML receiving imatinib or 2nd generation TKIs. Panels (A) and Istradefylline (KW-6002) (B) summarize the frequency of PD-1-expressing CD4+ T cells in patients with CML receiving imatinib (n?=?26) or 2nd generation TKIs (n?=?1 nilotinib, n?=?2 dasatinib, n?=?3 bosutinib and n?=?1 ponatinib). Panels (C) and (D) depict the frequency of PD-1-expressing CD8+ T cells in the same treatment categories. In the combination treatment group, 6 CML patients were treated with imatinib and 2 CML patients received nilotinib. 12967_2019_2194_MOESM3_ESM.tif (33M) GUID:?D6FAA7F3-F288-4F03-8D09-DF5C48505F3A Additional file 4. Frequency of myeloid-derived suppressor cells (MDSCs) in patients with CML receiving imatinib or 2nd generation TKIs. Panels (A-C) and (B-D) summarize the frequency of Gr-MDSCs and Mo-MDSCs, respectively, in patients with CML receiving imatinib (n?=?26) or 2nd generation TKIs (n?=?1 nilotinib, n?=?2 dasatinib, n?=?3 bosutinib and n?=?1 ponatinib). In the combination Istradefylline (KW-6002) treatment group, 6 CML patients were treated with imatinib and 2 CML patients received nilotinib. 12967_2019_2194_MOESM4_ESM.tif (31M) GUID:?EBB76CDE-87FA-44E9-A402-419366A4A148 Additional file 5. List of differentially expressed immune genes when comparing CML patients treated with TKIs plus IFN- and patients receiving TKIs alone. The differentially expressed genes (fold change?>?4 or?SERPINA3 mixed band of sufferers treated with TKI monotherapy, we.