Orphan GPCRs

2008), as well as for cytotoxic properties specially against leukemia cell lines such as K562 and HL-60 (Ito et al

2008), as well as for cytotoxic properties specially against leukemia cell lines such as K562 and HL-60 (Ito et al. Pharmaceutical market is definitely facing a productivity crisis, as there is a stagnant in the number of fresh drug approvals, and an increasing expenditure in the research and development processes (Rafols et al. 2014). Natural products have been proposed to develop fresh drugs that may be efficiently introduced into the pharmaceutical market (Butler et al. 2014), or as phytomedicines (flower components chemically and pharmacologically standardized). With this context, genus, a large group (180C200 varieties) of tropical trees belonging to the Peliglitazar racemate Calophyllaceae family, and primarily distributed in tropical regions of Asia, Africa, the Americas, Australasia, and the Pacific Islands (Stevens 1980), represent an important source of natural products, mainly coumarins, xanthones, flavonoids, biflavonoids, chromanones, and triterpenes, with significant biological activities such as cytotoxic, antiviral, chemopreventive, antisecretory, cytoprotective, analgesic, and antimicrobial properties (Saklani and Kutty 2008; Csar et al. 2011). Some varieties of this genus are used in folk medicine to treat peptic ulcers, malaria, tumors, infections, venereal disease, blood pressure, diuretic, pain, and swelling (Filho et al. 2009). Among spp. the two most important varieties are: which is definitely widely distributed in the American continent, from Brazil to Mexico, and located in Asia, Africa, Pacific region, and Australia. based on the kind of main compounds that are biosynthesized (Zavaleta-Mancera et al. 2011). recognition, or biotechnological approach. With this paper, we perform a scientometric and text mining analysis of chemical and biomedical study on genus focusing primarily on and spp. most of them (554) are unique papers, while the others are (Fig.?1). This claims that most of the research performed on genus offers focused on phytochemical studies, biological properties of such compounds, and ecology study. Open in a separate windowpane Fig.?1 Publications and main journals publishing study on inverted packed triangle: spp.; circle: value, as well as P, indicating an increasing in the interest of research on this genus; however, there are more P, CPP and PR on compared to is on this topic (Sanjid et al. 2013). On the other hand, for probably the most cited content articles have been for ecological applications, such as reforestation (Cusack and Montagnini 2004) (Fig.?1), nevertheless the CPP and PR on this varieties has been very low compared to spp.; spp.spp. are India, Brazil, USA, Malaysia and Japan, this is not surprising as most of these countries posses interesting study programs in natural products; moreover, the USA-NIH system for bioprospecting in collaboration with Malaysia authorities involved the development of calanolide A like a potential compound against HIV-1 that Peliglitazar racemate resulted in the creation of Peliglitazar racemate Sarawak Medichem Inc. Varieties of can also be found in the forest of several of the research innovator countries, such as India, Brazil, and Malaysia. Brazil is the innovator country on study, and India is the main country for spp. study, relating to Scopus database spp.genus, and are University or college of Putra, Malaysia, Universidade Estadual de Maringa, and University or college of Malaysia, respectively. This is not amazing as the University or college of Putra Malaysia possess an interesting system for developing new products (PutraInnotech) among them natural products. University or college of Malaysia is located at Sarawak. Table?2 and Fig.?2 display the main authors and co-authorship (more than five publications) leaders on study on spp. Richomme P. (Universite risks) is the main author and co-author head in research of this genus, since he has the highest quantity of publications, specially on and publications (Table?2) and one of the main coauthors with this topic (Fig.?2), he offers focused mainly on biodiesel Peliglitazar racemate applications of this varieties. Open in a separate windowpane Fig.?2 Main authors with more than 5 co-authorship research publications on genus, the density (size and have been focused on its enviromental and ecological applications; for instance, it has been Mouse monoclonal to XBP1 proposed the development of a phytomedicine (a draw out from your leaves comprising anti-HIV coumarins) as a strategy to impulse sustainable plantations, contributing to stop deforestation (Csar et al. 2011; Tapia-Tapia and Reyes-Chilpa 2008). Even so, there is an important amount of papers for anti-parasitic activities, mostly related to mammea type coumarins, antileishmania (Brenzan et al. 2007); and trypanocidal (Reyes-Chilpa et al. 2008), as well as for cytotoxic properties specially against leukemia cell lines such as K562 and HL-60 (Ito et al. 2006; Gomez-Verjan et al. 2014; Kimura et al. 2005), and antimicrobial properties mostly related to inhibition of (Pires et al. 2014) and (Su et al..